A quick glance at a map of Sevilla will show you a city divided practically right down the middle by the Guadalquivir River. You'll find the majority of the action on the eastern bank in the barrios (neighborhoods) of La Macarena, El Arenal, the centro, Santa Cruz, and María Luisa. However, don't miss the western bank barrios, especially Triana, as they offer up a less-touristy and certainly unique atmosphere of their own.
Be it by air, by rail, by road, or by sea, the ideally situated city of Sevilla has great accessability and tons of options to accomodate the needs - and wallets - of any traveller.